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Concerning gene conservation and function, 49 164 variants are mapped to one of the 2342 functional domains identified in the database (extracted from the Pfam protein family database (31), validated and propagated by MACSIMS) and 1799 HPO ontology terms from the HPO Human Phenotype Ontologyy) database (32).
Our findings provide the first structural view of the nGR subunits and a molecular framework for understanding the architecture, conservation, and function of nGRs.
While there may be different genome size biases in different taxa [2], [3], there are plenty of invertebrates with big genomes, and these do not look appreciably different – at least with regards to the landscape of non-coding sequence conservation and function – than comparably sized vertebrate genomes.
Despite active experimental and computational research, relationships among sequence, conservation, and function are still poorly understood.
Based upon sequence conservation and function, we refer to CNE-3 as chicken FIRE.
We investigated the relationship between sequence conservation and function of TF genes in C. elegans.
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Phylogenetic analysis of the soybean AP2_EREBP and rice ONAC families with their orthologs from other plant species, whose stress-responsive expression patterns and/or functions are known, resulted in a nearly perfect match between sequence conservation and functions or expression patterns.
For instance, phylogenetic analyses of the GmAP2_EREBP and GmNAC families of soybean and ONAC family of rice with their orthologs from other plant species, whose functions or stress-responsive expression patterns are known, resulted in a nearly perfect match between sequence conservation and functions or expression patterns.
To determine if there is a relationship between gene block conservation and the function of the gene blocks, we assigned each operon keywords based on its function.
The forest canopy is fundamentally important in biodiversity conservation and ecosystem function.
We show that SIRT1-ΔExon8 is expressed widely throughout normal human and mouse tissues, suggesting evolutionary conservation and critical function.
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