Sentence examples for conservation alignment from inspiring English sources
Sharan et al. (2005) used conservation alignment to find protein complexes that are common to yeast and bacteria.
Where the selected combination varied, we performed alignments with MAFFT and examined overall sequence conservation, alignment length, and number of indels.
Because the lack of tertiary structure removes purely architectural constraints on conservation, alignment of intrinsically disordered regions tends to highlight functionally important residues.
Each was evaluated for number of repeated homologs in the Pgt genome, region of conservation, alignment identity, expression in infected tissue, the dominant peptides, and their best detected fit to a protein structural model.
These false positive predictions could be removed through protein conservation alignments.
To measure proximal promoter conservation, upstream alignment scores of human genes were computed by counting the number of matches in the alignment between the sequence 1 kb, 2 kb and 5 kb upstream of the transcription start site and its syntenic mouse sequence.
In 1991, Sander and Schneider used Shannon entropy derived scores for positional conservation in alignment of proteins [12].
Using site-directed mutagenesis, missense mutants were constructed on the basis of conservation and alignment with known binding sites in PCTP.
Moreover, we confirmed that the results are not simply due to trivial technical factors, such as residue conservation or alignment gaps, and that similar results could not be obtained using uniform or randomized sets.
The relplot.pl script includes reliability annotation into secondary structure plots, colorrna.pl uses the conservation of alignments for coloring consensus structure plots, while coloraln.pl does the same with an alignment.
sRNA alignments against the target genomes are highly conserved (supplementary fig. S1, Supplementary Material online) and show higher conservation than alignments of E. coli– Shigella protein-coding genes (supplementary fig. S2, Supplementary Material online).
