The genomic region between 55 - 75 Mb on mouse chromosome 3 shows high conservation but a low density of disease gene orthologs.
Histone H4 (a highly conserved protein), SOD2 (a protein with an average degree of conservation) and Fibrinopeptide (a protein characterized by a low conservation level) were used as evolutionary markers [ 46].
Neutral mutations would have a low conservation index, whereas non-neutral (deleterious or adaptive) mutations would have a high conservation index [ 4].
Additionally, using the "Infernal" program we found that exon 1 had a conserved RNA secondary structure, but it failed to predict exon 2. Although there was a low conservation between tammar and eutherian mammals, tammar HOXA11AS was expressed in the endometrium during pregnancy as it is in humans, suggesting a conserved role in mammalian reproduction.
This suggests a low conservation of microsatellite flanking regions in this order regarding other fish orders of similar evolutionary age.
Multiple sequence alignment revealed a low conservation among the three subtypes with sequence identity of ∼10% between them, suggesting that the peptide repertoires presented by HLA-DR, -DP and -DQ are not overlapped to each other, and they may be involved in different immune functions and dysfunctions.
The results of the study highlighted that 27.5% of the collection required no treatment, 60% was deemed a low conservation priority and 12% required essential work.
The sequences here isolated from the B. oleae Y chromosome have no known related sequences on the Y chromosomes of other related genera, such as C. capitata: this may be indicative of a low conservation of sequence content.
Interestingly, not all introns show such a low conservation.
The Soloist protein, coded by a single-copy gene and characterized by a low conservation at the ERF DNA-binding domain, was present in all the plant genomes considered.
