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Consequently, unfolded or incorrectly folded exported proteins are very quickly degraded before they have a chance to (re)fold into their correct, protease-resistant conformation (Westers et al. 2006a).
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This supports the hypothesis that the cellular Michael adduct formation is responsible for ER stress activation via disrupting disulfide bond formation and consequently causing accumulation of unfolded proteins by the electrophilic olefine ketone [ 16].
Environmental stresses or similar events can easily provoke an overload of the ER folding machine, resulting in the aggregation of unprocessed proteins and consequently in the onset of the unfolded protein response (UPR) (reviewed in [ 63]).
However, if the ER stress is high and prolonged, the UPR will be unable to counteract the accumulation of various unfolded or misfolded proteins, and consequently other pathways may activate the apoptotic process (53).
TTP results from excessive platelet aggregation in multiple organs with, consequently, a dramatical increase in shear stress caused by the accumulation of unfolded high-molecular weight von Willebrand factor multimers in plasma.
The romance quickly unfolded.
Much unfolded from there.
Here is what unfolded.
It all unfolded quickly".
b) an unfolded word.
Then, something unexpected unfolded.
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