The extent to which such interventions can further increase the physical activity impacts of modifications to the built environment consequently remains unclear.
Some participants recalled a very reassuring diagnosis of CKD in terms of it not being a problem and consequently felt unclear about whether they had a health problem and what, if anything, they should be doing about it.
The minimum intensities in some included trials were lower than the aerobic intensity threshold for fitness improvements of 45% VO2R/60%HRmax proposed by Swain and Franklin [140], and consequently, it remains unclear at what point significant improvements in clinical outcome fail to occur.
However, we note that all miRNAs in this "intronic" cluster are coded antisense to LARP7 (supplementary fig. S3, Supplementary Material online), and, consequently, it is unclear to what extent there is overlap of expression profiles.
First, our methodological approach using ICA allows to evaluate functional interactions between brain areas but it does not provide information regarding causality and, consequently, it is still unclear whether functional changes are cause or consequence of repetitive migraine attacks.
Although four distinguishable DCIS morphologies are recognized, the mechanisms that generate these different morphological classes remain unclear, and consequently the prognostic strength of DCIS classification is not strong.
Despite its high prevalence, the pathogenic mechanisms of tendinopathy are unclear and consequently, current treatments are largely palliative.
In addition, whether or not the prescribing rates by different specialists differ depending on the characteristics of the drug remain unclear and consequently future studies will include studying the prescribing rates when including e.g. SSRIs in the analyses.
However, an observational follow up study, where all proposed prognostic factors in HF have been included has not yet been conducted in a large HF cohort and consequently it is still unclear if the effect of renal function and mortality risk can be explained by e.g. impaired diastolic function or other important confounders [ 18].
Which isoform of COX is responsible for postsurgical pain and, consequently, should be targeted, is unclear.
