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Consequently, randomised controlled trials using valid and reliable measures to compare surgery with conservative treatment and to evaluate different conservative interventions are needed [ 9].
Their primary question is: 'Does A cause B, everything else being equal?' Consequently, randomised controlled trials and regression models are the research methods of choice.
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Studies of treatment efficacy for lethal Vibrio species such as V. vulnificus, have inherent ethical difficulties and consequently there are no randomised control trials (RCT) of V. vulnificus in humans [ 2].
All seven trials selected for our systematic review have a scale reflecting high quality [ 34] and, consequently, were double-blinded and randomised.
The evidence for the effectiveness of clinical pathways in stroke is mainly limited to non-randomised studies and is consequently not strong.
The estimated screening failure rate is 15 20% and consequently we expect 125 patients to be randomised and included in the study.
For example, Williamson and colleagues used data from a study that developed a utility algorithm for the OM8-30 otitis media with effusion questionnaire 39 to predict preference based health related quality of life scores, and consequently QALYs, for children participating in a randomised trial of topical intranasal corticosteroids for persistent bilateral otitis media with effusion.
Because consent for treatment is often not obtained until after randomisation more participants, than in an individually randomised study, may refuse treatment and this will consequently dilute any treatment effects.
First of all, EDISSE is a non-randomised non-controlled observational study and consequently we have to be cautious in comparing the results between regions.
This reflects the lack of data from randomised controlled trials directly comparing different drug treatment options for resistant hypertension; consequently, there remains real clinical uncertainty about the preferred clinical management of such patients.
The multiple subgroup analyses suggested by Dr Currie seem ill-advised for a randomised trial, in that (1) the diminished sample sizes of the subsets, with consequently much wider confidence intervals for statistical testing, weaken the conclusions that can be drawn; and (2) multiple post hoc analyses increase the chance of 'uncovering' findings that are statistically significant but spurious.
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