This is because the crystal form dictates fundamental physical properties, such as density, solubility, hardness, melting point, mechanical strength, etc., and consequently can profoundly influence the manufacturing process, long-term stability, and performance of drug products (and any other fine chemicals).
The results suggest that the hormone-related pathways and consequently their crosstalk was profoundly affected by all Malus pathogens (Fig. 4, Supplementary Table 8).
Here, through a genome-wide genetic screen in Drosophila, we uncover a highly complex Notch-dependent genetic circuitry that profoundly affects proliferation and consequently hyperplasia.
MAMs have been recently described as lipid raft-like domains that orient proteins to promote the ER-mitochondria juxtaposition; consequently, alterations in their composition may profoundly affect the physical and functional inter-organelle crosstalk.
Thus, we suspect that hypophosphorylation AP tau mutation may profoundly block axonal transport and consequently inhibit synaptic vesicle transport.
Under both conditions, individual nutrients will gradually become growth limiting, and cause changes in the actual specific growth rates, that in turn may profoundly influence the metabolism and consequently the physiology of the cell.
We chose to score volant wing-propelled divers separately in both subdivisions as their aquatic locomotory strategy is known to profoundly influence wing bone morphology17,43 and, consequently, the expression of flight-related adaptations recorded therein43.
It is generally believed that age-related immune deficiency develops coincident with the gradual involution of the thymus gland and, consequently, that thymic-related (T-cell) functions are the most profoundly affected.
Both cytokines profoundly disturbed the distribution of ZO-1 and occludin and consequently affected the barrier function of the ARPE-19 monolayer.
Profoundly Loved, Profoundly Missed.
