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Since the 16 drugs are predicted to act on both genes in a synthetic lethal pair, they are consequently predicted to be effective individually as well.
The consequence is that proline is only slightly outside the range of variation represented by these two wild-type residues and is consequently predicted to be neutral or nearly so.
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For the 14 missense substitutions that Align-GVGD scored C0 and which we would consequently predict to be neutral or nearly so, assay results have been reported for 4 (p.R137Q p.R180H, p.R180H and p.T323P).
These Cb isoforms are missing 199 nucleotides, and consequently are predicted to encode a truncated polypeptide in which the 22 terminal amino acids of Math5 (VDPEPYGQRLFGFQPEPFPMAS) are replaced by 2 residues (VS).
16 Patients exhibiting primary non-responsiveness to TNF inhibitors are likely to have non-TNF-α-mediated disease and consequently would be predicted to respond better to subsequent therapy with an alternative mode of action.
The Mph1 helicase is known to catalyze dissociation of the invading strand of Rad51-generated D-loops or extended D-loops in vitro and consequently would be predicted to facilitate template switching during BIR (Sun et al. 2008; Prakash et al. 2009; Sebesta et al. 2011).
The role specialization model envisioned the price effect to surpass the income effect and consequently predicted women's employment to hinder childbearing and parenthood to jeopardize mothers' employment.
By contrast, mobile (unclustered) receptors have lower but uniform surface density; consequently, mobile receptors are predicted to mediate smaller quantal responses that have lower CV (MacGillavry et al., 2013).
By integrating gene expression data with a protein-protein interaction network, we found that mutations in sticky and dFmr1 resulted in misexpression of common gene networks, and consequently predicted additional specific phenotypes previously not known to be associated with either gene.
Additionally, another of the eight proteins is predicted to be a CAAT-binding factor (Additional File 2) consequently, it too is unlikely to bind to the G-box.
Consequently the Known Motif positive predictive power was 35% indicating that, on average, only 35% of sites predicted to be cleaved are expected to be true cleavage sites.
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