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Tumor regression induced by intratumoral IL-2 application may be a fast process (requiring about a week) in the case of a highly vascular tumor since IL-2 induces vascular leakage/edema and consequently massive tumor necrosis.
Consequently, massive efforts have been made to deal with these perceived deficits though a combination of top down interventions, accountability measures and changes in governance arrangements.
Consequently, massive iron overload, as present in hereditary hemochromatosis, frequently leads to diabetes (4).
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Therefore, impaired phagocyte recruitment to invading Candida under conditions of NADPH oxidase deficiency seems to be the cause of the overall reduction in containment of the infection and, consequently, of massive extracellular hyphal growth.
PRIMA-1 is a small molecule drug that reactivates mutant p53 by restoring its wild type conformation and transcriptional functions, consequently triggering massive apoptosis in tumor cells carrying mutant p53.
Given that IL-6 signals through STAT3 in B cells and can upregulate Blimp-1 expression [47], [61], it is likely that IL-6 enhances immunoglobulin production of developing plasma cells by maximizing Blimp-1 expression [61], which consequently upregulates the massive secretory apparatus program of plasma cells [47], [62].
Star Formation in the Early Universe: what drove the transition from Population III to Population II? Theoretical and observational evidence indicates that the first generation of stars to form in the universe were typically quite massive, and consequently lived short lives.
Taken together, these data suggest that numerous activating factors are highly enriched at group I promoters, indicating a massive regulation, which consequently leads to higher transcriptional activity ('hyperactive') (Fig. 5c and d; Additional file 1: Figure S3e and f).
This deposition occurs in crystal form thereby causing massive resorptive inflammation, with consequently swelling and redness of small joints, such as most preferentiallys the metatarsophalangeal and interphalangeal joints of the big toes.
Accordingly, those species possessing the lowest number of HME/HAE1 related sequences (B. mallei and B. pseudomallei strains) are those for which massive genome reduction (and consequently gene loss) has been documented [ 64].
Despite the superior lift performance result, PR-compliant wing also suffers from massive drag penalty, which has consequently affected the wing efficiency in general.
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