Differences in the activation/inactivation balance and consequently in the response to these substances may arise from differences in the enzymes involved.
For instance, a polymorphism located in the 5′ untranslated domain of thymidylate synthase, the target enzyme for fluoropyrimidines, is associated with a change in protein expression and, consequently, in cellular response to the drug (Pullarkat et al, 2001).
M. leprae can cause very different disease phenotypes in humans, probably due to individual variation in genetic profile and, consequently, in immune responses.
Highly absorbent, retaining as much as 16 to 18 percent of its weight in moisture, wool becomes warmer to the wearer as it absorbs moisture from the air, thus adjusting its moisture content and, consequently, its weight, in response to atmospheric conditions.
Patients who develop septic shock and who are consequently maximally stressed, in response to an infection, may exhibit adrenal insufficiency.
Thus, it is likely that melanocytic cells are more sensitive to a telomeric DDR compared with cells in epithelial tissues and consequently arrest earlier in response to telomere dysfunction.
Based on numerical results and a securitization using a generalised trainload pattern, it is demonstrated that the primary frequency contents in the trainload, and consequently in the dynamic response of the bridge, is largely governed by the bridge-to-carriage length ratio.
The difference in the level of the fertility status of the soils consequently gave colossal difference in response level to fertilizer applications.
Yeast Rec8 lacks the Chk kinase phosphorylation site and consequently cannot become cohesive in response to DNA damage.
We can hypothesize that in tumours carrying a wt TP53 gene, the balance between HMGA1 and PATZ1 protein levels might have opposite effects on the activity of p53 and, consequently, in tumourigenesis and in response to anticancer treatments.
