In conclusion, we have demonstrated a functional requirement for PICH and BLM in the resolution of centromeric anaphase threads and consequently in the maintenance of centromere integrity.
As a evolutionarily conserved lncRNA, which is also involved in maintenance of chromatin structure in normal cells, Hotair might become abundant in stochastic clones that consequently gain survival and migration advantages over other cells and potentiate distal metastasis, as proposed previously for the well-documented cancer-initiating cells [ 36].
Genes such as histidine kinase (drk1) regulates the transition of mycelium to yeast and consequently the maintenance of virulence in B. dermatitidis and H. capsulatum [ 16].
Therefore, glucagon utilisation is important since this hormone shows a fundamental role in glycemic control and, consequently, the maintenance of homeostasis.
This implies that osteoblast activity is coordinated by both the external stimuli and the internal osteoblast clock to maintain the diurnal rhythms in bone formation and resorption, and consequently the maintenance of bone mass.
The absence of FOXC2 (S I = 2∗105 molecules) results in low levels of ZEB1 mRNA and consequently the maintenance of epithelial phenotype (Fig. 6b, bottom panel) irrespective of the high levels of SNAIL (Additional file 1: Figure S10).
In summary, neonatal estrogen defeminizes the hypothalamus such that the coordination of steroid positive feedback on GnRH neurons and, consequently, the maintenance of a regular ovulatory cycle are curtailed.
Inhibition of fission machinery, and consequently maintenance of fused mitochondria, abrogates ROS generation, suggesting that mitochondria fuse to control ROS production [6], [7].
Duplication through polyploidy allows concerted duplication of interrelated genes and consequently, maintenance of proper gene balance [ 53].
We show that chemical uncoupling inhibits HSC activation and consequently stimulates the maintenance of the quiescent phenotype.
