Our results illustrate the potential of metabolomics in cellular drug-target engagement studies and consequently have broad implications in future drug development and target validation ventures.
Conclusions: Traditional medicine appears to be a more significant component of Mongolian health care than is reported in the international literature and consequently may deserve additional attention in future studies of the country's medical system.
The biosensor is specific for Tdp1 even in complex biological samples, such as human cell extracts, and may consequently find future use in fundamental studies as well as a cancer predictive tool allowing fast analyses of diagnostic cell samples such as biopsies.
Bicyclists caused the heaviest burden on the medical sector; consequently, they need to be prioritized in future safety work, as recently declared in the Government plan Vision Zero 2.0.
Therefore,the contribution of infill masonry panels should be considered in the structural response analysis of existing buildings, for which understanding the out-of-plane non-linear behaviour of IM walls is paramount to develop efficient strengthening solutions to prevent and improve their performance in future earthquakes and, consequently,to reduce their seismic vulnerability.
Furthermore, we demonstrate the presence of highly expressed proteins whose activities have not been previously linked to EBPR and which, consequently, may need to be included in future metabolic models.
Directional, purifying selection occurs when successive amino acid changes (i.e. non-synonymous changes) improve protein efficacy and consequently the changes tend to be fixed in future lineages, thereby reducing overall genetic diversity.
It is hypothesized that modern plant breeding reduces genetic diversity in elite cultivars, consequently jeopardizing future crop improvement [ 5].
30 31 34 We hypothesise that metformin administered to obese women during pregnancy will reduce birthweight centile in their babies and consequently their future life risk of obesity and metabolic syndrome.
