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Stress-induced up-regulation of CYPs that metabolize the majority of prescribed drugs can result in their increased metabolism and consequently, in failure of pharmacotherapy.
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On the other hand, JNK signaling loss may lead to defects in Bim/Bmf function and consequently to failure of luminal clearance.
These examples shall exemplify learning from damages and consequently preventing failure of components and structures in the future.
It is basically known that particle size, morphology, and number affect the biologic response resulting in an osteolysis that finally leads to an aseptic loosening and consequently to failure of the prosthesis [ 7, 8].
Information on any of the proteins involved in oocyte growth and systemic lipoprotein transport in the laying hen was lacking until 1989, when it was demonstrated that the absence of a 95-kDa protein in R/O hens is responsible for the impaired uptake of VLDL into oocytes in-vivo and, consequently, for the failure of oocytes to develop normally (Nimpf et al., 1989).
Depletion of this protein results in no PCM forming around centrioles and consequently failure of spindle assembly [5].
Reduced proliferation and increased apoptosis has been observed in mammary epithelium lacking Id2, resulting in the failure to form alveolar structures and consequently failure of lactation [ 64].
In obese and diabetic patients, hepatic steatosis results in a failure of insulin action and consequently leads to excessive hepatic glucose production (HGP) and fasting hyperglycemia [6].
These data suggest that during an infectious process HO-1 displays a crucial role in the failure of neutrophil migration to the infectious focus, and consequently in the susceptibility in severe sepsis.
Britain, she contended, is consequently in violation of European law.
He is eternally overbooked and consequently in a position of power.
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