MiRNAs regulate key biological processes such as development, differentiation, stress response, apoptosis and proliferation [ 9– 11] and are consequently implicated in several diseases including cancer [ 12– 12].
In fact, we had previously proven that JNK is involved in APP phosphorylation at Thr-668 and is consequently implicated in the production of soluble A β oligomers.
MiR-143 and miR-145 have previously been shown to suppress cell growth in CSCC and they have consequently been implicated in cervical carcinogenesis (Wang et al, 2008).
These alterations have the potential to interrupt or activate multiple genes, and consequently have been implicated in cancer development [ 3].
Altogether, our findings consistently implicate activation of DNA damage response signaling, and consequently the involvement of the mismatch repair pathway in the cascade of molecular events following TPA exposure of non-malignant HRBECs.
Reorganization of chromosomal territories has been associated with changes in the epigenetic regulation of gene expression [ 11] and consequently may also be implicated in functional changes resulting from long-term culture of primary cells.
These upstream and downstream kinases of AMPK have fundamental roles in glucose metabolism, fatty acid oxidation, protein synthesis and tumour suppression; consequently, they have been implicated in cardiac ischaemia, arrhythmias and hypertrophy.
Also, magnetic beads could replace the use of the centrifuge, although our preliminary results implicate that commercially available beads still co-purify a considerable amount of contaminations (not shown) and consequently require improvements.
"But to implicate a maid.
You need to implicate someone.
