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The energy minimization of a small molecule alone does not automatically stop at a local minimum of the potential energy surface of the molecule if the minimum is shallow, thus leading to folding of the molecule and consequently hampering the generation of the bound conformation of a guest in the absence of its host.
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Declining and ageing populations mean fewer people in the workforce, which in turn can lead to a decrease in economic productivity, which consequently hampers growth.
This would consequently hamper the use of flux data for model validations and/or up-scaling exercises (Turnipseed et al. 2002; Wilson et al. 2002).
In recent years, it seems that the number of jellyfish have been on the rise, fueling concerns that their voracious appetites for microscopic sea creatures might have a negative impact on the food web and that their density might alter how fish behave young fish seek refuge among the jellies' tentacles, for example—and consequently hamper the ability of predators to catch these fish.
Distortions in the depth channel may generate wrong objects contours or shapes in the rendered images (see, for example, Figure 1d,e) and consequently hamper the visual user experience manifested in headache and eye-strain, caused by wrong contours of familiar objects.
High household costs of illness lead to impoverishment; they impair affordability and equitable access to health care and consequently hamper tuberculosis (TB) control.
The use of special and consequently expensive equipment hampers the breakthrough of active suspensions.
Such natural disasters have caused damage to some bridges, consequently isolating residential communities located on mountains, and hampering the ability to delivery emergency relief supplies to those communities.
Much effort has been made to develop recombinant versions of SP-A and SP-D, but rfhSP-D, previously accumulated into inclusion bodies during expression in E. coli and, consequently, the production was hampered by the requirement of denaturing agents and subsequent refolding.
Merck's yeast-made Gardasil and GSK's insect-cell-made Cervarix are VLP-based vaccines both highly effective/powerful but not cost-effective; consequently, their use is hampered in developing countries where HPV accounts for ~85%% of both annual cervical cancer cases (~500,000 cases worldwide) and deaths from cervical cancer (~300,000 worldwide) [ 4].
But competition is hampering negotiations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com