Sentence examples for consequently downstream from inspiring English sources

Upon agrin stimulation MuSK becomes tyrosine-phosphorylated, which induces recruitment of downstream factors and consequently downstream signaling [25,27,36].

Molecular machineries sense DNA strand breaks and activate the kinases ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) and consequently downstream pathways involving the activation of p53 [ 22, 23].

First, chronic RyR sensitization alters RyR expression, and consequently, downstream Ca2+-dependent events that regulate dendritic growth in an inverted dose-related manner, perhaps because of negative feedback at the higher A1254 dose.

The various P2Y receptor subtypes are functionally coupled to different G proteins, and, consequently, downstream signaling pathways, either phospholipase C, with inositol 3 phosphate (IP3) formation and intracellular calcium increase, or adenylyl cyclase, leading to modulation of cyclic adenosine monophosphate (cAMP) production [ 78].

Consequently, downstream uses of this effluent, whether to maintain streamflow and quality, groundwater recharge, or irrigation may be impacted.

Consequently, downstream effectors such as eukaryotic initiation factor 4E-binding protein (4E-BP1) as well as S6 kinase (S6K1), which mTOR regulates through phosphorylation [ 34], were reduced.

Signal perception by RK-ECDs induces activation of intracellular kinase domains and consequently initiates downstream signaling.

We establish that, among our engineered multiepitopic formats, trans-triepitopic antibody fusions demonstrate optimal efficacy, inducing rapid EGFR clustering and internalization and consequently ablating downstream signaling.

IKKγΔ is defective in TANK binding and consequently recruiting downstream TBK1·IKKι, a kinase complex essential in IRF3 phosphorylation.

These higher levels of IGF-1 and IGF-2 promote IGF-1R signalling and the consequently activated downstream pathways.

All of these studies reveal myosinIIA is important for centripetal movement of TCR microclusters within the IS by inhibiting actin dynamics and consequently affecting downstream signalling [ 38 ].