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Additionally, CCL2 has been described to interact with endothelial cells [ 68] consequently disrupting the BBB.
RNA foci are thought to cause cellular toxicity by sequestering specific RNA-binding proteins in a sequence-dependent manner, consequently disrupting their function [ 4].
One of the most widely recognised topical agents is 5-fluorouracil (5-FU), a chemotherapeutic agent, which works by inhibiting thymidylate synthetase and consequently disrupting DNA synthesis.
In the HD-0716 case, the c.1685A>G p.Asn562Ser mutation may affect the VEFS-box known to be critical for EZH2 interaction, consequently disrupting PRC2 function.
While facultative for the majority of parasite pathogens, gametogenesis and fertilization are obligate steps of the Plasmodium life cycle (Heitman, 2010), consequently, disrupting either process prevents infection of new hosts.
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"While desire focuses on the other, always in a somewhat fetishist[ic] manner, on particular objects, like breasts, buttocks and cock," writes Badiou, "love focuses on the very being of the other, on the other as it has erupted, fully armed with its being, into my life that is consequently disrupted and re-fashioned".
That is, this self-binding traps the Zen practitioner into a mode of attachment that is the source of suffering and, consequently, disrupts the sense of embodied freedom it cherishes.
Because of the excess amount of internal free volume associated with the molecular cavities in the pentiptycene moieties and the consequently disrupted chain packing, all the polyimides exhibited high fractional free volume (FFV) leading to high gas permeabilities as well as good selectivities that are highly desired for gas separation membranes.
These changes can consequently disrupt the precise hexagonal outlines of ommatidia and if sufficiently severe lead to rough adult eye phenotypes.
It is possible that the C-terminal of 1 240 aa covered the ubiquitination site of 1 200 aa and consequently disrupted the reliability of the hyperthermia.
The biological activity of disulfiram is attributed to its ability to bind divalent cations and consequently disrupt metal dependent processes, particularly those involving copper and zinc [2,3].
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