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The contribution of valproate to the onset of hypotension is consequently difficult to determine.
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Behavioral treatments, such as CBIT, tend to involve multiple components and, consequently, it is difficult to determine whether all components are necessary for all patients.
Ovarian cancer is a heterogeneous disease displaying complex genomic alterations, and consequently, it has been difficult to determine the most relevant copy number alterations with the scale of studies to date.
As treatment with the echinocandins fails to completely inhibit growth in Aspergillus species, it is difficult to determine a clear point of inhibition and consequently an accurate MIC is hard to define.
For example, the question of where adsorption (e.g., pollutants) by clay particles occurs, in interlayer or interparticle spaces, is difficult to determine because the particles are not inert and consequently the size and the shapes of the pores are varying continually with the environment.
It is difficult to determine precisely whether a particular job "requires" a college degree, and consequently measuring underemployment is a thorny process.
Though the iron and hydrogen peroxide studies utilized RNA from broth-grown cells in mid-log phase, the growth phase of anaerobically grown gonococcal cells is difficult to determine due to the requirement for growth on solid media, and consequently, this may also affect the comparison of these results with other studies [ 74, 75].
The answers are difficult to determine.
The truth was difficult to determine.
That has been difficult to determine".
The prevalence is difficult to determine.
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CEO of Professional Science Editing for Scientists @ prosciediting.com