Platinum chemotherapy generates interstrand cross-links that can only be adequately repaired by HR-based DNA repair, and consequently BRCA1-deficient and BRCA2-deficient cells are highly sensitive to platinum chemotherapy both in vitro and in vivo.
Together these data suggest that Eater is required for plasmatocytes to enter the sessile state, and that consequently, eater deficient larvae have close to double the number of freely circulating plasmatocytes that wild type larvae have.
We conclude that many neonates treated for acute respiratory failure sustain significant hippocampal atrophy as a result of the associated hypoxia and, consequently, show deficient memory later in life.
YM1 is a chitinase family protein that is found in macrophages and myeloid cells located in the spleen and bone marrow and, also, pulmonary macrophages [ 28]. p47phox knockout mice are phenotypically similar to Cybb-/ mice since they both have defective phagocyte NADPH oxidase complexes and are consequently, superoxide deficient.
A SIM- and consequently SUMOylation-deficient mutant of SLX4 was unable to rescue SLX4-knockout MEFs treated with the DNA-crosslinking agent mitomycin C (MMC).
Does the introduction of VE-cadherin in N-cadherin (and consequently VE-cadherin) deficient cells restore tumor growth?
Johansson and Hildingsson 36 found that 46% of fathers who witnessed emergency caesarean section judged the partner's medical intrapartum care as most deficient, consequently affecting their birth satisfaction.
In B cells, miR-155 is important for immunoglobulin class-switching by plasma cells and, consequently, miR-155-deficient mice have impaired IgG levels during humoral responses [ 17, 30].
In a previous article, the group showed that mTXNPx-deficient promastigotes are significantly more sensitive to a temperature shift from 25°C to 37°C than wild-type promastigotes and, consequently, the mTXNPx-deficient parasites were unable to survive within the mammalian host [ 152].
