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We hypothesized, that activation of the cardiac adenosine-A1 receptor by capadenoson would reduce stimulation-induced NE release and consequently blunt the heart rate response during physical stress particularly in SHR.
One significant barrier to therapeutic stimulation of anti-tumor immunity is constituents of the tumor microenvironment [10] such as secreted immunosuppressive factors [11], myeloid-derived suppressor cells [12], and regulatory T cells [13], that adversely affect DC activation and consequently blunt the generation of anti-tumor immunity.
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The effect causes a reduction in the rate of glucose absorption and consequently blunts the postprandial plasma glucose rise [26].
Inhibitors of these enzymes delay carbohydrate digestion, causing a reduction in the rate of glucose absorption and consequently blunting the post-prandial increase of plasma glucose [ 23].
Inhibition of these enzymes delays carbohydrate digestion and prolongs overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise [ 26].
However, the phenomenon of original antigenic sin results in the competition between preexisting and newly developed immunity and thereby attenuates the immune responses to current viral infection, and consequently may blunt the protection from current influenza infection.
Why does James blunt exist?
Well, let me blunt.
This will blunt them.
He seems to approach photographs as blunt instruments; consequently his show lurches around the social landscape, leavening moments of brutality and ineptitude with glimpses of tenderness.
In this setting, antibody must act mainly through cytotoxicity [8], and alpha- and beta-herpesvirus consequently encode receptors that blunt Fc-dependent attack [9], [10].
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