Sentence examples for consequently activating from inspiring English sources

Studies have shown that TLR3 pathway is critical in the pathogenesis of PBC [ 24- 26], and poly I C, a synthetic double-stranded RNA, can mimic the infection of retroviral RNA by interacting with TLR3 and consequently activating the innate immunity with series of cytokine production and activation of lymphocytes.

Therefore, while on the one side the HDAC inhibitor panobinostat functions at the histone level, acetylating and consequently activating the GADD45G promoter, on the other side the SIRT1 activator may function at the transcription factor level, deacetylating and consequently inhibiting the function of the GADD45G repressor.

These findings could be explained by the fact that AMPK stimulates NAD+ production, consequently activating SIRT1 which promotes energy production and homeostasis [21].

Activation of the IKK complex leads to the phosphorylation and degradation of I κB, consequently activating NF κB [ 25, 33].

In addition, increased expression of miR-21 has been associated with loss of heterozygosity at the PTEN locus, consequently activating the Akt pathway and promoting tumorigenesis [ 77, 78].

MiR-1246 was reported to be a target of the p53 family, and inhibits Down syndrome-associated DYRK1A, consequently activating NFAT1c and inducing apoptosis (Zhang et al, 2011).

Growth factor stimulations significantly increase the dimer/tetramer PKM2 ratio in cancer cells and consequently activate the protein kinase activity of PKM2.

Of note, irradiation caused activation of SRC which consequently activated PI3K, p38, and AKT, thereby promoting EMT through SLUG expression in breast cancer cells.

Taken together, these results suggest that radiation promotes the EMT program by SRC-mediated activation of PI3K and p38 MAPK that consequently activates AKT signaling in breast cancer cells.

24, 25 In summary, our findings suggest that radiation promotes the EMT program by SRC-mediated activation of PI3K and p38 MAPK that consequently activates AKT signaling in breast cancer cells.

The sensor kinase Gcn2 regulates expression of the transcriptional activator Gcn4 under conditions of amino acid deprivation, which consequently activates FLO11 expression and pseudohyphal growth [ 21, 33].