Sentence examples for consequently abolished from inspiring English sources

Inhibition of S1046/47 resulted in reduction of EGFR trafficking, consequently abolished activation of EGFR and inhibited upregulation of phosphorylation at tyrosine residues including Y1068.

Interestingly, when HNE was maintained for 14 hours in cultured chondrocytes, through repeated treatments at intervals of 2 hours, the aldehyde induced both COX-2 and mPGES-1 expression up to 24 hours and consequently abolished their decrease.

Some deletions on OspC may cause this special structure to collapse and consequently abolish the protective function.

The mdx mouse, the most widely used animal model for Duchenne muscular dystrophy, carries an ochre nonsense mutation in dystrophin exon 23 [47] that drastically reduces the abundance of dystrophin mRNA and consequently abolishes dystrophin expression [48].

Importantly, co-expression of Gab1ΔSHP2 in this system blocks the EGF-induced increase in the phosphatase activity of the NS-associated SHP2 mutants and consequently abolishes their positive effect on EGF-induced ERK phosphorylation [ 202].

For instance, a recent study indicated that reactive oxygen species (ROS) may oxidise HMGB1 to form an intramolecular disulphide bond between the thiol group of Cys106 and Cys23 or Cys45, and consequently abolish HMGB1-mediated immunostimulatory activities (Ref. 151).

We found that the downregulation of uPAR and cathepsin B by pUC-inhibited TGF- β1-induced expression of XIAP and pSMAD-2 expression, consequently abolishing invasion and cellular proliferation in these cells.

It should be noted however that for several protein solutions that had been irradiated with 30 kGy, especially the ones dissolved in HEPES buffer, the absorbance peak was completely abolished and consequently there was no detectable λmax (Fig. 3C E and Table 3).

In contrast, the W232A mutation in PSTPIP1 abolished pyrin binding; consequently, PSTPIP1 filaments were primarily straight, not extensively branched (Figure 4I K), confirming that the reticularization of PSTPIP1 filaments is a direct consequence of pyrin binding.

Therefore they are abolished.

In the strain lacking acy1, cAMP production is abolished [ 26] and consequently the situation resembles that in the strain lacking env1.