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An increase in ASA (i.e. atrial enlargement) while preserving the same VSA, would result in a reduced hydraulic force and consequently a reduced LV filling and impaired diastolic function.
Hypothetically, a reduced activity of the viral EPS depolymerase on the RD5PR2 EPS material and/or different exopolymer composition with a higher DNA or protein content to EPS could strengthen the RD5PR2 biofilm compared to PpG1, hereby leading to a hampered flow through of phage and consequently a reduced RD5PR2 biofilm degradation.
The result is local vasoconstriction and, consequently, a reduced blood flow.
The higher concentrations of AA required for the inhibitory effects of ABT-737-induced apoptosis were most likely associated with the inactivation of cPLA2 and consequently a reduced basal AA concentration in this case.
Point mutations in inlA are presumably caused by localized recombination and lead to a truncated InlA protein and consequently a reduced invasion phenotype in human intestinal epithelial cells [ 67- 70].
Recent evidence suggests pyruvate from enhanced glycolytic activity results in increased acetyl CoA competing for the limited available carnitine in the mitochondria and consequently a reduced fat oxidation (Jeppesen and Kiens 2012).
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The HES group did not compensate for hemorrhage and consequently had a reduced albeit positive acid-base balance after hemodilution.
The authors describe how short-term application of anti-angiogenesis drugs, such as sunitinib, leads to increased metastasis in animal models and consequently to a reduced median survival compared to vehicle-treated groups.
Thus, in HD patients, when renal impairment is increased, GPx activity is lower, and, consequently, there is a reduced ability to detoxify hydrogen peroxide, as GPx is considered to be the primary defense for elimination of these reactive species in erythrocytes [ 31].
The increase of t-PA can be judged by an elevation of tPa - tPa inhibitor complexes and a consequently reduced fibrinolysis due to an increase in tPa- inhibitor concentration [ 12].
This translates into a reduced ability for dispersion and emulsification, consequently reducing irritability to ocular structures [ 41].
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