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However, conservative treatment in non-selected cases usually requires prolonged periods of bed rest (with consequential functional disability), which is not recommended for elderly persons who often have other diseases and poor general conditions.
In summary, the genetics of SLE is still not fully understood, but by undertaking additional genetic studies and consequential functional assays we will obtain a much greater understanding of the etiology of the disease.
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The pathogenesis is reflected by reduced capillary perfusion, tissue ischemia (according to the pattern of capillary damage) and the consequential structural and functional damage.
These results support that CNA patterns in myeloma, such as the eight characteristic trisomy chromosomes in about half of all myeloma patients, are not a by-product of myeloma genomic evolution but have functional and consequential effects that contribute to the pathogenesis of myeloma.
Notably, ceRNAs are not always functionally consequential (42, 43).
Increases in dPGC-1 preserve mitochondrial functional efficiency without consequential changes in ROS.
This is a 'bias-correction' solution that has been shown to correct for remaining finite sample bias, while potentially also making violations of functional form assumptions less consequential [35, 36].
Knee-extensors were fatigued in six studies [ 19- 24], of which four consistently showed consequential detrimental effects on balance and functional tasks [ 19- 24].
The author proposes not to act in the structural vulnerability, as "there is no way to reduce the hazard or it is unknown (e.g. for terrorist attacks) and constructions are already built and maintained in an optimal way" but to act in the functional vulnerability, defined as the consequential degree and duration of capacity reduction.
It was shown also that evolutionary flexibility of cyclin function may be provided by consequential reorganization of regions on protein surface remote from CDK binding sites in animal and fungal cyclins and by functional differentiation of paralogous cyclins formed in animal evolution.
Biologically active substances related to inflammation together with other predisposing factors may compromise the functional integrity of this barrier with a consequential MT in uveitis [ 32, 33].
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