In the case that DNA fidelity is compromised, prolonged p53 and consequential TPPP1 expression contributes to the initiation of apoptotic cell death programs (Fig. 1H).
Furthermore, it would be very difficult to identify and validate, for example, K M values and maximum glucose uptake rates, as these inevitably vary along the radius of the cell pellet, owing to the varying glucose concentration and the consequential differential expression of the hexose transporters.
On the contrary, in OT cells, the same siRNA effectively knocked down HSF1 expression (P<0.01), causing large increases in ER stress makers (P<0.05), presumably due to the significant consequential decrease of HSPs' expression (P<0.05).
At the end of the process, we identify a small subset of genes which exhibit disruption through multiple mechanisms and show consequential change in gene expression.
Pathological events such as carcinogenesis can be caused by alteration in established methylation patterns or dysregulation of chromatin remodeling, both of which can result in significant and consequential changes in gene expression (Das and Singal 2004; DeAngelis et al. 2008).
In fact, reduced IGF-I levels in circulation may be the main factor behind extended lifespan in dwarf mice, such that with respect to liver, the only expression change consequential for longevity determination is that of the IGF-I transcript.
This study did not support the hypothesis that spontaneous de-methylation events in the HLA-G promoter play a primary role in the development of precancerous cervical lesions through HLA-G re-expression and consequential promotion of viral and tumor escape from immunosurveillance.
Although differences in gene expression are not necessarily consequential for fitness, if variation in regulatory sequence affects gene expression (or that similarity in sequence reliably corresponds to no variation in gene expression), then intraspecific variability in regulatory sequence could be used as a preliminary screen for evolvability.
Curated by Renée Mussai, the exhibition offers insights into a consequential, but largely overlooked, aspect of black culture and political expression in Britain.
It remains unclear how mammalian cellular systems overcome this intrinsic noisiness of gene expression to produce consequential variations in function, and what impact this has on the biologic and clinical relevance of highly 'purified' cell subgroups.
As we have reviewed, the number, arrangement, sequence, and position of HSEs is consequential for heat-shock gene expression.
