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It now seems more likely that, rather than being plunged back into a medieval deep-freeze, consequential changes in the Gulf Stream will merely slow the warming of Europe.
Between 2000 and 2006, there were 18 states with consequential changes in the minimum wage11.
The second is that there are consequential changes in the microstructure.
The phenotypic effects of mutations are determined through consequential changes in the secondary structure of the mutant RNA molecule, which in turn determines its replicability, decay rate and enzymatic efficiency.
Use of comparative risk assessment is a further means whereby uncertainty is reduced by the consideration of carefully matched comparators (isogenic lines, cropping managements, environments) in order to focus on aspects of the comparison that represent substantive, consequential changes in the crop or system under consideration.
The general sequence of steps in signal transduction are (i) binding of a ligand to a receptor, usually to an extracellular receptor embedded in the cell membrane, (ii) phosphorylation of intracellular enzymes, (iii) amplification and propagation of the signal, and (iv) consequential changes in the cellular function, for example, increase/decrease in the expression of one or more genes.
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Rather than an abrupt departure, same-sex marriage is the culmination of a larger and ultimately more consequential change in the nature of marital relations between men and women.
Chief executive Andi Case said: The multi-cyclical and volatile nature of our markets has once again been demonstrated by the sudden shift in oil and other commodity prices which, when coupled with the evolving economic environment, has given rise to a consequential change in the demand supply balance in many markets.
In a Critic at Large that ran in 2004, Adam Haslett discussed how the debate over same-sex marriage illuminated already-existing changes in the traditional notion of matrimony: Rather than an abrupt departure, same-sex marriage is the culmination of a larger and ultimately more consequential change in the nature of marital relations between men and women.
A consequential change in the use of the factor capital of 0.09% after this moderate cost increase is substantial.
Hence, the most consequential change in the biology of an infectious pathogen is when it makes the transition from a non-sustainable infection to a rapidly spreading infection when it crosses the threshold at R0 = 1.
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