Sentence examples for consequential activation from inspiring English sources

Thus, disruption to one element of the MAPK signalling network may conceivably cause consequential activation of other components.

The expression of genes encoding for ICAM-1 and TNF-α is controlled by the nuclear factor NF-κB. Site-specific phosphorylation of the inhibitor IκB leads to its degradation by proteasome and to a consequential activation of the NF-κB pathway.

In ruffles, IκBα can be degraded with consequential activation of NFκB [ 103].

KRAS mutation and the consequential activation of the MAPK kinase axis are regarded as major driving forces of PDAC progression.

However, the presence of NHERF1 and consequential activation of the PKC pathway are important for normal bone growth, as NHERF1 null mice showed a reduction in the rate of bone reabsorption as well as bone formation, resulting in bone that is 25% weaker because of a lack of collagen cross-linking.

It has been advocated that ASCL1 expression may favour cancer cell growth through repression of DKK1 with the consequential aberrant activation of the Wnt/β-catenin signalling pathway [ 9].

This phase is characterized by increased production of proinflammatory cytokines and consequential synovitis, osteoclast activation and development of erosions.

We found that acute exposure to high 20% oxygen tension promotes Akt and mTOR signaling pathways activation, with consequential increase of mTOR downstream targets (Stat3 and p70S6K), whereas hypoxia inhibits these effects.

Consistent with our study, short-chain fatty acids were shown to induce ROS production, which led to AMPK activation and consequential mTOR inhibition.

Early cytokine release syndrome (CRS) in CAR therapies has been related to multiple factors including γ-interferon (IFNγ, TNFα, IL1, IL2 and IL6, and may contribute to anti-leukaemic effects, but consequential inflammation and macrophage activation syndrome (MAS) can mimic sepsis with hypotension, fever rigours and vascular leak syndromes (Brentjens et al, 2013).

These findings suggest that the migration of B cells from peripheral blood into lymphoid tissues might be occurring during active CVL, with activation and differentiation of these cells in the plasma cells and consequential polyclonal activity leading to a high production of anti-Leishmania antibodies.