However, what is important is to ask whether such differences are consequent to Notch activity during axon target sorting.
Consistent with the possibility that the PRMT5-dependent effect on OPC differentiation was consequent to its enzymatic activity on histone arginine residues, which in turn prevented re-acetylation during differentiation, we showed that pharmacological inhibitors of KAT histone acetyltransferases were sufficient to overcome the differentiation block and rescue both survival and differentiation.
All the above analyses led us to conclude, hence, that the differential response of chromosomal flanking genes to the accumulation of helical tension is not consequent to the atypical transcription activity of subtelomeric regions.
The study area is criss-crossed with lineaments consequent to a number of tectonic activities in the past.
Deletion of fragments comprising sequences from −980 to −450 was without effect on basal promoter activity, contrasting with the pronounced decrease in transcriptional activity consequent to loss of the region between −450 and −100 (Fig. 2B).
In this scenario, the AA6 dependent boost of TET activity, consequent to increased expression and nuclear re-localisation, suggests AA6 as a promising tool to counteract metastasis formation in experimental breast cancer.
Abnormalities occurred during two distinct phases; in the early neonatal period, when [3H]hemicholinium-3 binding sites are transiently overexpressed, and during or after the period of rapid synaptogenesis, when binding in controls is rising consequent to the increase in nerve impulse activity.
Interestingly, RET/PTC and the RET/MEN2A oncoproteins have constitutive kinase activity consequent to ligand-independent dimerisation (Monaco et al, 2001).
Some animals showed severe signs of atrophic fibres and changes in fibre type proportion, probably caused by altered electrical activity consequent to slowed nerve conduction.
In addition, hemodynamic factors consequent to a decrease in renin-angiotensin activity could be considered as a factor.
The effect was only minimally detected in proliferating cells and suggested that the decreased survival of OLs in the absence of PRMT5 activity was consequent to the elimination of an aberrantly differentiating cell.
