However, the motor deficit characteristic of the human P301S tau transgenic mice probably results from the degeneration of spinal cord motor neurons, consequent to the development of a toxic filamentous tau pathology (Allen et al., 2002; Delobel et al., 2008), and possibly the sequestration of proteins important for motor behaviour.
This development was consequent to the perceived inadequacy of the two previous paradigms to cope with the problems set by the evolution of science and technology, as they both presuppose either an identifiable author (fault) or some reliable data (risk) to assign responsibilities.
The use of innovative approaches in drug delivery field is required by the need of carriers for new biological therapeutic agents, such as nucleic acids and proteins, but also by the pharmaceutical companies due to the upcoming patent expirations and the consequent interest in the development of novel formulations.
For example, Funk and Schnellmann demonstrated a persistent disruption of mitochondrial homeostasis after AKI, which in turn may result in suboptimal cellular respiration, reduction in cellular adenosine triphosphate (ATP) and consequent tissue dysfunction, all contributing to the development of chronic damage [ 21].
Here, we provide evidence that expression of Satb1 and the consequent effect on the development of SST+ interneurons depend on Lhx6 activity.
Our objective was to determine whether there is a relationship between IL 1-α levels in milk and smoking habits in nursing mothers, with the consequent implications on the development of the immune system.
Mutations in eukaryotic RNA methylating enzymes, and a consequent change in methylation, can lead to the development of diseases and disorders.
Aberrant signalling occurring from EGFR results in its conversion into an oncoprotein, and the consequent malfunction of cellular signalling networks leads to the development of cancers and other proliferative diseases.
The use of recombinant proteins has increased greatly in recent years and as a consequent the development of techniques for their purification has significantly increased.
The present results support the theory that difficulty in maintaining sleep or having persistently shallow sleep could result in the induction of insulin resistance and consequent the development of diabetes.
Thus, continuous high expression of Slpi and a consequent reduction of corneocyte desquamation seem to underlie the development of keratinized cysts in aged mice.
