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In this scenario, the AA6 dependent boost of TET activity, consequent to increased expression and nuclear re-localisation, suggests AA6 as a promising tool to counteract metastasis formation in experimental breast cancer.
Concordant with these reports, we have also observed increased expression of TWIST1 protein in MC cells consequent to forced expression of TFF3 (unpublished data).
We have also observed increased expression of SNAIL, and TWIST1 in ER+ MC cells consequent to forced expression of TFF3 (unpublished data).
Consequent to this increase in APOBEC expression, high levels of HBV hypermutation have been observed, reaching 35% of the sequences in some cases [ 206].
The penetrance of SIOD therefore appears to be dependent upon the magnitude of the alteration of gene expression consequent to SMARCAL1 deficiency.
For both experimental strains, various conditions were systematically evaluated to optimize growth characteristics, maintenance of viability consequent to FeHm starvation and reproducible regulation of gene expression.
For both experimental strains various conditions were systematically evaluated to optimize growth characteristics, maintenance of viability consequent to iron and heme starvation and reproducible regulation of gene expression.
The production of this compound may be increased consequent to exogenous gliotoxin exposure in wild-type due to up-regulation of gliP expression.
The expression of CHD1, GREB1 and KPNA2 is hence required to promote cell growth consequent to miR-26 depletion.
Actin mRNA levels were not modulated consequent to calcium stimulation.
are sufficient for the consequent to hold.
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