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This design is expected to aid in increasing local effectiveness, thus reducing the systemic loading and the consequent side effects of colistin.
Patients will be prescribed inappropriate psychotropic drugs with consequent side effects, complications, and costs.
The individuals concerned undergo unnecessary further investigations and treatment, with all the consequent side effects, and the health care system has to bear the unnecessary costs.
These designs might cause plasma concentrations larger than desired maxima of endogenous substances with the consequent side effects such as the case for corticosteroids, and an idealized treatment regime is not obtained.
High-frequency TMS has two main advantages: (a) it reduces the time a patient spends in the "off" state because the individual dose of these profound diurnal fluctuations leaves a person slow, shaky, stiff, and unable to rise from a chair; (b) it allows the reduction of medications and their consequent side effects [ 117].
Finally, the study of the molecular regulation of GBM resistance to VP-16 is of utmost importance, as the effectiveness of VP-16 treatment is restricted because of its use in high doses, and consequent side effects, in recurrent GBM patients.
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Because normal, rapidly dividing cells are exquisitely sensitive to cytotoxic agents, the consequent side-effects of cytotoxic therapy are not uncommonly significant in producing dose limitation and cessation, causing either delayed therapy, dose reduction, poor compliance, alteration of therapy type, complete cessation of therapy, or rarely, early death.
This means that, in order to attain neuroprotective leves in the CNS, systemic high-dose rhEPO would have to be given, with the consequent unacceptable side effects (Juul et al., 2004).
The potential advantage of Tpl2 as therapeutic target over ERK1/2 is its selective activation by inflammatory stimuli with a consequent reduction in side effects.
They reduce estrogen levels in order to inhibit the pain symptoms but without triggering side effects consequent to estrogen deprivation.
However, similar to antibiotics and corticosteroids, they are associated with undesirable side effects consequent to prolonged use [ 14, 22– 28, 29, 29].
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CEO of Professional Science Editing for Scientists @ prosciediting.com