Exact(2)
On the other hand, loss of Δψm could induce the opening of the permeability transition pore in the inner mitochondrial membrane and consequent rupture of the outer mitochondrial membrane, which may allow the release of proteins that reside in the intermembrane space, including cytochrome c, to activate the caspase cascade that executes the apoptotic program [51], [52].
The consequent rupture of mitochondrial integrity then triggers the release of various proapoptotic mitochondrial factors, including cytochrome c, into the cytosol, where they activate the apoptotic cascade leading to cell death [ 23].
Similar(58)
However, in case 1, the mucosal necrosis and consequent mucosal rupture (laceration) were mild, and no damage caused by the ischemia was observed in the submucosal layer, muscular layer, or serosa.
Fluid buildup and swelling with the consequent tissue rupture occurred mostly within the first to fourth day after injury (Fig. 1C).
The consequent intracellular rupture of lysosomes with the abrupt introduction of their harmful highly acidic content containing a spectrum of extremely potent hydrolytic enzymes would certainly lead to rapid digestion of polypeptides, nucleic acids and biomembranes and consequent cell lysis.
Structural analyses revealed more ruptured cells and free juice in pulled apart sections, suggesting improved integrity of intercellular connections and consequent cell rupture due to failure of the primary cell walls under stress.
Formerly, a group of researchers have also reported the bactericidal potential of silver ions against S. aureus and E. coli which have been known to bind with negatively charged bacterial cell wall resulting in rupture and consequent denaturation of proteins which leads to cell death [23].
This predisposes the aneurysm to rupture and consequent bleeding.
Endogenous Nef produced in infected cells can cause lysosomal permeabilization, with release of cathepsin-D into the cytosol and consequent outer mitochondrial membrane rupture.
They are believed to result from mechanical trauma to the excretory duct of the salivary glands, causing duct transection or rupture, with consequent extravasation of mucin to the connective tissue stroma (mucus extravasation phenomenon, MEP).
Since the 1970s, regulators and operators have identified premature aging problems including vibrations in pipes, with consequent cracking, leaks and ruptures that in turn cause severe corrosion, leading to worse leaks and ruptures.
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