Costs associated with treatment received consequent to relapse may account for the largest share of treatment costs in schizophrenia [ 1- 4], which is one of the most expensive to treat psychiatric conditions [ 5].
The first cluster of such high-risk patients had high MRD during induction 1, in both PB and BM, with a consequent clinical relapse during 48 76th week of treatment i.e., between second and fourth maintenance.
A possible explanation for this is that it is entirely possible that tumour growth rate may be slowed by neoadjuvant therapy (as measured, for example, by a reduction in proliferation factor Ki67) without a formal clinical response being achieved but with a consequent gain in relapse free survival.
Although the introduction of systemic chemotherapy based on CHOP (cyclophosphamide, doxorubicine, vincristin and prednisone) regimen and high-dose methotrexate followed by radiation therapy has consistently improved survival, the prognosis of PCNSL still dismal, with high rates of local relapse and consequent death.
These practitioners felt that people with CFS/ME may be stigmatised in the workplace, pressurised into downplaying their symptoms; living in fear both of losing what they have and of having a relapse due to consequent overactivity.
Thus the use of FLAG-Ida induction in Pgp-positive cases induces a slight shift in initial efficacy, such that efficient clonal reduction results in improved CR for this subgroup, but these patients have an increased frequency of relapse with a consequent lack of effect on OS.
Owing to side effects and the length of treatment, patients often partly or completely drop off therapy, with a consequent rise in drug-resistant strains and cases of infection relapse.
The consequent loss of adequate exposure to therapy is likely to lead to relapse and hospitalization.
Thus, moderation of impulsivity with consequent minimization of craving might be responsible for the lower rates of relapse in the topiramate augmentation group.
But since a long time is required to overcome the relapse effect, we observe the intersection of the robustness curves and the consequent reversal of their robust dominance.
