Our findings could help to prevent local cell growth/invasion and possible consequent recurrences.
Low down it indicates that an attempt to perform an anterior resection will carry a high risk of an involved margin (CMI) and consequent local recurrence.
52, 53 Unlike infliximab and similar to adalimumab, the combination of slow absorption rate following SC administration, slow elimination rate, and appropriate dosing frequency give etanercept a smooth and uniform concentration-time profile, minimizing the occurrence of overexposure and resultant adverse events, as well as underexposure and consequent symptom recurrence.
81 Similar to etanercept, the slow absorption rate following SC administration, slow elimination rate, and appropriate dosing frequency give adalimumab a smooth and uniform concentration-time profile, minimizing the occurrences of overexposure and resultant adverse events, as well as underexposure and consequent symptom recurrence.
In view of the consequent improvements in recurrence rates and in overall survival, the development of effective adjuvant treatments for colorectal cancer is considered as one of the most important to be made in clinical oncology over the last decade.
All these approaches appear to lower costs at the price of increasing the risk of HBV recurrence with consequent graft damage.
These results could be explained by the destruction of the lining of the endometrium with the consequent impossibility of endometrial polyp recurrence despite the existence of oestrogen stimulation.
However, three major questions remain: (i) How do some tumoral cells have the ability to integrate nerve structures (between the endoneurium and the perineurium mainly) to use those contaminated nerve fibers as a route for locoregional spread and consequent regional invasion or local recurrence after resection?
Given the long time between surgery and sampling in VICTOR and consequent sampling bias against early recurrence, we suggest that a requirement is an analysis of telomere length and survival based on a set of CRC cases sampled close to diagnosis, ideally before chemotherapy, and with excellent follow-up data.
This might be a reflection of more concern about the risk of breast cancer recurrences and the more consequent recall policy of the radiation oncologist.
