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This causes a compensatory influx of sodium to maintain electroneutrality and a consequent influx of water, extracellular dehydration, and formation of thick mucus in the airways [ 7].
The breakdown of phospholipids causes severe changes in the structural and functional integrity of the plasmatic membrane with a consequent influx of calcium ions [ 62], release of calcium-dependent proteases [ 63], activation of endogenous PLA2s [ 64], and mitochondrial collapse [ 65].
As such, our findings might reflect a necessity for Splunc1 in maintaining homeostasis in the middle ear space, with loss of Splunc1 resulting in increased cell death and debris and a consequent influx of inflammatory cells.
Interestingly, these cardiomyocyte miRNA-deficient mice developed heart failure with supposedly consequent influx of non-myocyte cells like leukocytes and fibroblasts as contributors to the increased presence of these miRNAs.
To facilitate the consequent influx of registrars and prevocational trainees [ 4] the number of registrar training places will double between 2008 and 2014, and the number of prevocational places is expected to more than double between 2009 and 2013 [ 5], impacting on training costs, supervision loads, and service capacity [ 6].a Similar problems are occurring on an international scale [ 7].
Using the mitochondrial uncoupler carbonyl cyanide 4- trifluoromethoxy phenylhydrazone (FCCP) and thapsigargin to empty intracellular Ca2+ stores, we found that the initial increase originates from emptying of the endoplasmic reticulum and consequent influx of extracellular Ca2+, whereas the late increase originates primarily from mitochondria.
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Binding of agonist to nAChRs results in conformational changes to the receptors, with consequent ion influxes.
A collapse of the EU-Turkey deal and the consequent large migrant influx could have catastrophic effects.
A similar requirement for external Ca2+ and the consequent transsarcolemmal Ca2+ influx was documented in adult cardiomyocytes [9], [31], [32], hESC-CMs [19] and mouse ESC-CMs [33], [34].
Those positive feedback loops rely implicitly on ongoing neuronal activity to sustain Ca2+ influx and consequent activation of the MAPK cascade [41] and/or PKA.
The consequent reduction in Ca2+ influx may lead to reduced myocardial contractility and vasodilatation, thus saving ATP.
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CEO of Professional Science Editing for Scientists @ prosciediting.com