Despite the plethora of publications and guidelines, the data consistently show a lower uptake of evidence-based investigations and therapies in older patients with consequent higher rates of HF hospitalizations and mortality [ 43].
While this may have biased the study towards inclusion of more severe or persistent cases (with consequent higher rates of thoughts of death or suicidal ideation) it also would have favoured the inclusion of those young people with more persistent thoughts of death or overt suicidal ideation.
Similarly, disseminated TB is occurring in large numbers of children living in overcrowded slums in Mumbai with a consequent high death rate (9); we attribute many of these deaths in children to primary multidrug-resistant TB.
The review reveals the need for more modelling of deciduous forest, for progressively more sparse forest and for forest in regions with intensive storms and the consequent high rainfall rates.
Insufficient specificity of the HPV DNA assay results in a high false-positive rate and extra medical burden because of the consequent high colposcopy referral rate [ 6].
These infections have serious consequences, including high rates of chronic suppurative otitis media [ 3], bronchiectasis [ 5], rheumatic heart disease [ 6, 7] and impaired growth and development [ 2, 8] permanent hearing loss [ 9] and consequent poor educational outcomes [ 10].
Nonetheless, the marked sensitivity of the T. brucei bloodstream parasite to NMT inhibition can be attributed at least partly to the high rate of endocytosis/exocytosis and the consequent high turnover of plasma membrane in the flagellar pocket [ 13].
Under this perspective, the higher gene flow rate of host grasses and their consequent high genetic variability would constitute an essential mechanism for the ecological resilience and contemporary evolution of the symbiotum (Saikkonen et al. 2004; Gundel et al. 2010).
We suggest that the lack of mitochondrial supercomplex organisation and the consequent lack of respiration is a requirement to maintain a high rate of aerobic glycolysis in order to fulfil the primary human neutrophil functions.
Almost all trials showed a considerable and consistently high rate of recurrence of emetic symptoms after placebo highlighting the need for a consequent antiemetic treatment.
