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Therefore, we hypothesized two possible causal pathways leading to enlargement of the external gills: a multi-step pathway, via the anti-predator behavioural change and the consequent deficiency of oxygen uptake (hypoxia); and a direct pathway, via predator-derived signals of predation risk (Figure 1).
Antibody responses and cell-mediated immunity are seriously impaired, probably because of atrophy of the thymus and the consequent deficiency of helper T cells.
Iodine deficiency and consequent deficiency in thyroid hormones result in goiter.
The mechanism producing this change is uncertain, but may relate to endothelial dysfunction and a consequent deficiency in NO-mediated vasodilator activity.
Other authors (Mickelson et al. 1977, Agamanolis et al. 1985b) did not find modifications of PGs: they believed that the alteration of the growth plate is due to a metabolic factor (with consequent deficiency and disarray of collagen fibrils) and to a mechanical factor.
The enrichment of Cdipt expression in the larval GI tissues accounts for the strong GI defects in hi559 larvae due to functional loss of Cdipt and consequent deficiency of de novo PI synthesis, in spite of maternally deposited PI in the yolk.
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They may have been developed without consumer input, with consequent deficiencies apparent [ 7].
58 Conversely, withholding iron therapy with consequent iron deficiency may increase the risk of infections.
In ZDF myocardia and HF-exposed cardiomyocytes we have described an increase of cytosolic and mainly mitochondrial ROS, consequent ATP deficiency, and apoptosis.
Together, these results suggest that increased arginase activity in asthma may be a contributing factor to the decrease in the circulating levels of Larginine and the consequent NO deficiency.
Thus, our study provides evidence that the ND2 subunit participates directly in the proton pumping mechanism of complex I. Together, our findings support the model that diminished respiratory chain activity, and consequent energy deficiency, are responsible for the pathogenesis of complex-I-associated neurodegeneration.
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