Sentence examples for consequent defect from inspiring English sources

Deficiency in CARMA1 (originally known as CARDII) resulted in selectively impaired activation of NF-κB induced by the TCR and a consequent defect in interleukin-2 (IL-2) production.

Current treatment modality preferred in bone and soft tissue tumors is wide resection of tumor followed by the reconstruction of consequent defect by various methods.

The consequent defect in cellular ATP production was evident as a dramatic inhibition of autophagolysosomal maturation, which requires a high rate of ATP consumption to fuel lysosomal acidification.

Its promoter methylation is directly involved in tumor progression, causing MMR dysfunction and consequent defect in repairing DNA replication errors [ 26, 27].

Our study reveals that the expression of TBRII is significantly increased in SSc MSC, with a consequent defect in the production of collagen type 1α2 in response to TGF-β activation.

The lack of asymmetry, determined either as the loss of asymmetric subcellular localization of PCP proteins or as the consequent defect in the positioning of wing bristles and/or individual ommatidia, has been shown to be a powerful tool for studying the PCP pathway in Drosophila melanogaster [ 27].

Here we demonstrate that selective elimination of Rac1 in excitatory neurons in the forebrain in vivo not only affects spine structure, but also impairs synaptic plasticity in the hippocampus with consequent defects in hippocampus-dependent spatial learning.

The biochemical features of reduced Pex7 function were reproduced in this model, including tissue plasmalogen deficiency, phytanic acid accumulation, reduced import of Pex7 ligands and consequent defects in plasmalogen biosynthesis and phytanic acid oxidation.

This confirms that loss of GCase activity and consequent defects in autophagy impair α-synuclein turnover.

Proofreading would emplace a last line of defense against SNARE assembly errors and consequent defects in cell architecture and function.

Given the role of DNASE1L3 in DNA degradation in apoptosis, loss of function of the protein and consequent defects in DNA clearance might contribute to the production of ACA [ 26 ▪, 27 ▪].