Sentence examples for consequent activation from inspiring English sources

These data suggest that activated ROS and consequent activation of JNK could be involved in increased DR4 and DR5 expression.

We conclude that the ability of this integrin to activate FAK and the consequent activation of Ras and induction of GLI1 expression underlie its contribution to tumour initiation.

Ligand binding generally causes dimerization of the receptor and consequent activation of the tyrosine kinase activity of the intracellular cytoplasmic domain to mediate intracellular signalling.

Taken together, our data suggests that WA by inducing ROS activates JNK-dependent phosphorylation and consequent activation of TAp73 by targeting TAp73/MDM2 interactions.

Those positive feedback loops rely implicitly on ongoing neuronal activity to sustain Ca2+ influx and consequent activation of the MAPK cascade [41] and/or PKA.

Since degradation of I-κBα and the consequent activation of NF-κB are pivotal steps for TNF-α-activated gene expression [23], [24], we examined whether Thy-1 modulates degradation of I-κBα.

The IRF3-Bax complex translocates to mitochondria and triggers the release of cytochrome C to the cytoplasm; consequent activation of the caspases causes apoptosis.

Further, phosphorylation and degradation of inhibitory κB and consequent activation and nuclear translocation of the redox-sensitive transcription factor NF-κB were significantly prevented by benfotiamine.

Abnormal distension of meningeal blood vessels and consequent activation of the trigeminal neuron system, the principal pathophysiolgy of headache of migraine [6], is exactly opposite to the pathophysiology of the proposed hypothesis of vertigo (i.e., vasospasm of the artery).

The data herein clearly showed that G-Rh2 triggers p53-dependent Fas expression and consequent activation of caspase-8 and p53-independent caspase-9-mediated intrinsic pathway to cause cancer cell death.

The unique LRR domain might function in specific recognition of a BPH effector, with consequent activation of the defense response, possibly through induction of a SA-dependent resistance pathway (Du et al. 2009).