Sentence examples for consequences on the function from inspiring English sources

Consequently, their deterioration can have important detrimental consequences on the function and plasticity of neurons, and is thought to have a pivotal role in ageing and in the pathogenesis of several neurological disorders.

A VUS is an alteration in the gene sequence with unknown consequences on the function of the gene product or risk of causing disease.

This conformational change can have a range of consequences on the function of target proteins, altering catalytic activity, stability or subcellular localization (for review see Lu and Zhou, 2007).

While a lot has been and continues to be learned from these types of experiments, recent evidence has shown that such artificial constraints may have significant consequences on the functioning of the neural circuits of spatial navigation.

To conclude, we expect that such alteration of functional relationships by differences in dispersal ability between species will have strong consequences on the functioning of metacommunities.

Although several aspects of the pathogenesis of AD remain unsolved, the turnover and degradation of APP and Aβ in the mitochondrial compartment appear to be two fundamental processes whose dysregulation might lead to dramatic consequences on the functioning of the organelle, and ultimately, of the cell as a whole.

The procedure for predicting the functional consequences on the protein function is as follows (see Supp. Fig. S1 for a flow diagram detailing the procedure): the JackHMMER component of HMMER3 (one iteration with the optional –hand parameter applied; see Supp. Fig. S2) is used to search for homologous sequences within the UniRef90 [Suzek et al., 2007] database (November 2011).

The materials, the dimensions and the geometry were varied and the consequences on the response function were studied.

Thus, it will be interesting to study the effects of exercise training on the myocardial microcirculation and the consequences on the cardiac function of diabetic rats.

Therefore either the frameshift observed in pilQ has no major consequences on the protein function, or alternative secretins such as XpsD and or XcsD are recruited.

The hydrolysis of the glycan of IgG has been shown to have major consequences on the effector functions of the antibody by modulating the binding to FcγR [ 12].