Sentence examples for consequences on the expression from inspiring English sources
We demonstrated an association between one GHSR promoter SNP and weight loss during a 3-year follow-up and consequently showed that this SNP might have functional consequences on the expression of the GHSR gene.
We specifically tested Sox2 and indeed overexpression has negative consequences on the expression of markers of terminal differentiation, Filaggrin and KRT10.
Decreased levels of minor snRNPs such as U11 may further enhance this situation and have deleterious consequences on the expression of mRNAs containing U12-type introns in cells of SMA patients.
This has consequences on the expression of Fas and Dlx5.
In another study lack of Pkh1 or Pkh3 had not relevant consequences on the expression profiles [ 17].
During cell wall assembly, biosynthesis of phenylpropanoid, protein, and carbohydrate constituents appeared to be inter-dependent, and the deficiency in a key-enzyme of the lignin pathway had consequences on the expression of several genes involved in cell wall metabolism.
We have not conclusively proven the functional role of any polymorphism in regulating the expression of CEGs through in vitro or in vivo experimental validation, and many of the SNPs in the vicinity of the CEGs could be neutral (i.e. have no consequence on the expression levels).
This result is consistent with the deleterious effect of abiotic stress on photosynthesis (Chaves et al., 2009) and shows the consequences of that effect on the expression of genes involved in the metabolic processes dependent on photosynthetic products.
Disrupting critical circadian clock genes not only disrupts rhythmicity of target gene expression, but it can also have dramatic consequences on the level of expression of many target genes [ 73. 76- 77].
There are a number of methodological challenges associated with the detection of methylation at the PTEN CpG island and in determining the consequences of methylation on the expression of PTEN.
We assessed the consequences on miRNA expression by northern blot analysis probing for the highly abundant, hepatocyte-specific miR-122, which has been previously noted for its long half-life (Gatfield et al., 2009) and thus served as a proxy for overall miRNA depletion from hepatocytes.
