Regarding the 4 remaining mutants, His51Ala, His57Asp, Cys138Ala and Phe13Leu, their consequences on unfolding curves and Tm shifts were less pronounced, suggesting that these mutations have more limited effects on folding and stability of MtPncA.
Despite extensive studies motivated by their central role in physiological functions and pathological role in neurodegenerative diseases and cancer, the precise mechanisms of tau and stathmin binding to tubulin and their consequences on microtubule stability are still not fully understood.
Compared to the relatively subtle effects on the speed of retinal angiogenesis and endothelial cell proliferation, astrocyte VEGF deletion had more pronounced consequences on vessel stability.
By contrast, more recent evidence shows that the absence of individual sarcoglycans has indirect consequences on DGC stability.
Our results suggest that a fraction of cancer-associated UTR-SNPs may have functional consequences on mRNA stability and/or expression.
Altogether, these results provide evidence that at least a subset of cancer-associated SNPs might have functional consequences on mRNA stability and/or expression.
As suggested in the literature [ 19] and demonstrated with the significant direct correlation between Hb variability and number of epoetin dose adjustements, this fact could have favourable consequences on Hb stability.
Evidence of gene suppression and phenotypic consequences on developmental stability and canalization were obtained for Hsp22, Hsp67Ba, Hsp67Bb, and Hsp67Bc knockdown, whereas results from RNAi targeting of Hsp68 and Hsp70Bb were inconclusive.
In fact, although we were manipulating the largest scaffolding subunit of the proteasome, only a small number of the mutations we studied had any negative consequences on proteasome stability.
