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To further explore the possible functional consequences of this altered Foxm1 expression, cytoplasmic and nuclear protein extracts from the whole cochlea of E18.5 and P15 mice were analyzed.
This suggests that achieving a skewed CD8 Treg ratio may be predictive of long-term tumor control, as described recently with other immune-modulating antibodies.[22], [23] We next investigated possible functional consequences of this altered intra-tumor Teff Treg ratio by exploring the effects of GITR ligation on tumor-specific CD8+ effector cells.
The phenotypic consequences of this altered gene expression are, however, beyond the scope of this paper.
The consequences of this altered Ca2+ regulation are likely to be manifold.
Further analyses will be required to better understand the functional and therapeutic consequences of this altered methylation signature.
Neither the mechanism nor the consequences of this altered gene expression is understood at this point, and overall this study raises several questions for which follow-up research will be necessary.
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A consequence of this altered metabolic state is the increased production of pyruvate.
In order to study the consequences of the altered chemokine homeostasis in Alox15 -/- mice, we investigated CXCR2 expression on neutrophils.
This may also be the case in the elderly, but studies investigating the metabolic consequences of the altered elderly microbiota are required.
However, it is yet unclear whether these may also represent an indirect consequence of the altered mpt expression (see below).
Another important consequence of the altered hepatic Hh signaling may concern the reproductive capacity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com