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Note that all of the variants identified from the GWAS findings are in non-coding regions and the functional consequences of these variants remain largely unknown, thus follow-up sequencing studies and functional experiments will be required.
The biological consequences of these variants are unknown.
A lack of functional assays has hampered the conclusive validation of the consequences of these variants.
Further investigation into the functional consequences of these variants is under way.
Although they had no effect on expression, functional consequences of these variants could not be excluded with certainty.
It will be of interest to identify the actual causal variants and to elucidate the functional consequences of these variants.
Similar(46)
Therefore, the most likely consequence of these variants is down regulation of gene expression.
This is necessary to allow the functional consequence of these variants to be analyzed before a drug is prescribed.
Functional consequences of these rare variants were assessed by evaluating serum FI antigenic measurements.
Paracchini et al. studied the functional consequences of these sequence variants in lymphoblastoid cell lines [ 9].
It is possible that these genetic loci have pleiotropic effects on reproductive timing as well as other biological processes leading to breast cancer, and the observed associations might be due largely to other biological consequences of these risk variants that do not manifest themselves as changes in age at menarche or age at natural menopause.
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CEO of Professional Science Editing for Scientists @ prosciediting.com