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With this rise in survival, there has been increased interest in the quality of life (QOL) and consequences of therapy for breast cancer survivors.
Thus, the combined targeting of at least sGC and ERα would make it difficult to interpret the phenotypic consequences of therapy based on YC-1.
Somewhat less than half of the patients will ultimately die of disease progression [ 56] and therefore should be treated aggressively; however, if every patient is so treated, the majority will suffer the adverse consequences of therapy unnecessarily.
Long-term registries of patients receiving all types of radionuclide therapy should be considered to monitor possible long-term consequences of therapy as well as efficacy so that protocols suggesting best sequencing of therapy can be evaluated.
The current health care environment requires decision-makers to consider the fiscal, as well as the clinical consequences of therapy (i.e. cost-effectiveness analyses) when allocating limited health care dollars.
Long-term consequences of therapy include painful and often debilitating lymphedema due to surgery or radiation therapy, and reduced vaginal lubrication and hot flashes due to long-term hormonal therapy.
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Because mechanical stimuli regulate scar remodeling, the long-term consequences of therapies that alter infarct mechanics must be carefully considered.
Awareness of deleterious side effects and renal consequences of therapies in the modern NICUs and improved post-discharge care and longitudinal renal follow-up as well as parental and health care provider awareness are warranted.
A deeper knowledge of how mutation rates can affect fitness and adaptive ability can be of great importance to evaluate the effectiveness and long term consequences of therapies, especially those based on the increase of the mutation rate through the use of mutagens [45].
Intensive care consists of supporting failing organs while striving to minimize iatrogenic damage, and the longer term consequences of therapies are only just becoming appreciated.
Nevertheless, those who survive often suffer from neurologic, endocrinologic and social sequelae as a consequence of therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com