Sentence examples for consequences of the variants from inspiring English sources
In all, the functional consequences of the variants identified as strongly associated with increased risk of normal tissue toxicity following radiation exposure suggest a high biological plausibility for our findings.
Since we observed that one variant could have consequences for more than one transcript/gene, subsequent filtering was performed using the consequences of the variants instead of the variants themselves.
Functional consequences of the variants were produced by using the Ensembl VEP (McLaren et al, 2010).
The ancestral/derived alleles and functional consequences of the variants were identified from the Ensembl database of genomic annotations (www.ensembl.org).org
Ensembl Variant Effect Predictor, including SIFT (http://sift.jcvi.org/) and PolyPhen (http://genetics.bwh.harvard.edu/pph2/), was used to predict the functional consequences of the variants (http://www.ensembl.org).org
Potential functional consequences of the variants can also be assessed using methods such as SIFT [ 14], PolyPhen [ 15], and SeqHBase [ 16, 17].
If a certain hANT4 variant is found to be associated with a human disease, functional consequences of the variant is readily testable using the expression system and techniques described here.
By applying a custom-made data analysis pipeline, we have annotated the detected variants, including reported single-nucleotide polymorphisms (SNPs), genomic location, predicted miRNA binding sites, consequences of the variant in transcripts (i.e. synonymous, missense) and protein function prediction for those variants that are predicted to result in an aminoacid sustitution.
Furthermore, it was demonstrated that, when dealing with martensite, local elastic properties change, as a consequence of the variants reorientation, and this effect has to be taken into account for the fatigue crack growth characterization.
The high frequency of pol β variants identified in tumor-derived tissues suggests a possible role in the progression of cancer, making the determination of the functional consequences of these variants of interest.
