The authors outline the placebo designs considered in ADAPT, discuss their advantages and disadvantages, and provide their rationale for and the consequences of the selection of the double placebo design.
The consequences of the selection of an anti-mutator mutant in a population previously mutagenized have not been explored, but they could be quite negative from the viewpoint of the host if, as predicted by our model, they are associated to a short term increase in the adaptive ability.
As a consequence of the selection of Lagrange polynomials for element shape functions discrete orthogonality is obtained leading to the diagonal form of the element mass matrix.
However, fouling depends on thermofluidynamic conditions (e.g. flow velocity) which values are consequence of the selection of design variables (e.g. baffle spacing).
A consequence of the selection criteria for investigated atom types is that all bonds in tetra-coordinated hexa-valent carbon (0.81% of 85,894 substances) are considered to be covalent and this atom type does not pass the valence check during structure standardization.
Differences in the codon bias between species arise as a consequence of the selection pressure, which results in the non-uniform usage of synonymous codons within a gene.
These are likely to occur as a consequence of the selection pressure provided by the novel environment the metastasised tumour cells find themselves in.
The emergence of p53-mutated cells during nutlin-3 adaptation may be the consequence of the selection of a preexisting p53-mutated sub-population or nutlin-3 may favour the formation of novel p53 mutations in p53 wild-type cells.
It is acknowledged that the misuse and overuse of antibiotics in agriculture, aquaculture, animal husbandry, and the clinic have caused an increase in AR bacteria, the consequence of the selection pressure exerted in these environments [ 3, 32].
The discrepancy between such a low percentage of MSI and the higher percentage of MSI reported in earlier studies might be the result of many reasons, such as a variable definition of MSI-H, the use of different markers, or a consequence of the selection of patients (Popat et al, 2005; Müller et al, 2008).
