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"What are the long-term consequences of the mutation?
First, kinetin as an FD treatment would potentially decrease deleterious consequences of the mutation at the protein level.
Finally, via an in silico analysis clues to structural and functional consequences of the mutation in the β-myosin heavy chain were obtained.
Figure 7A compares the response of WT channels with F1473C channels to this voltage protocol and several consequences of the mutation are readily apparent.
Even though the MCR4 mutations we studied are relatively rare (∼5% of severe obesity), the obesity phenotype allowed them to be identified and rapidly tested for the biochemical consequences of the mutation.
To evaluate the clinical consequences of the mutation on the pA3731 gene, we used an in vivo model of acute pneumonia in which the parental or the mutated strains are injected intratracheally to mice.
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This mutational genetic variance both depends on the mutation rate and on the phenotypic consequences of the mutations (the mutational effects).
X-ray crystallography was used to identify the structural consequences of the mutations.
Possible functional consequences of the mutations were analyzed using protein modeling and structural mobility analyses.
The significance of the large pfserca polymorphism and the consequences of the mutations described here on the protein's function and regulation are unclear.
The putative consequences of the mutations were also evaluated with the help of several software programs.
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