Scientists, divers, environmentalists and the media must all make a concerted effort to shift the global consciousness and communicate the very real, very serious threats facing sharks and the potential consequences of sustained inaction.
To directly address the consequences of sustained Hh signaling in neocortical precursors, the neurosphere culture assay was utilised to test for stem and progenitor cell properties [29].
A serial histopathological examination of the prostates from iBRAF* transgenic males was conducted to assess the long-term consequences of sustained BRAF* expression in the prostate epithelium.
The fat-1 mice provide a good model for investigating the specific consequences of sustained increases in formation of n-3 fatty acids from n-6 fatty acid substrates.
First-generation BET inhibitors have shown therapeutic efficacy in preclinical models, but the consequences of sustained BET protein inhibition in normal tissues remain poorly characterized.
Next, we examined the consequences of sustained Brd4 knockdown in adult tissues by initiating Brd4 silencing in 3- to 5-week-old mice.
Although radiation-induced inflammation has been studied in mammalian models, flies offer a number of advantages to further our understanding of acute inflammation following radiation and the long-term consequences of sustained inflammation.
Where aberrant Wnt signalling is evident, as occurs in vivo with the functional FrzB SNP, FrzB-/ or the Col2a1-CreER T2; β- catenin fx(Ex3)/wt β-catenin cAct mouse, abnormal loading induced by joint misalignment, excessive load or traumatic injury could exacerbate downstream consequences of sustained Wnt signalling leading to a homeostatic imbalance of matrix catabolism over synthesis.
The assumed causal mechanism is based on the idea that multicultural policies "do not provide strong incentives for host-country language acquisition and for interethnic contacts" (Koopmans, 2010, p. 3) and "stimulate migrants to orient themselves towards their ethnic community, may have the unintended consequence of sustaining linguistic deficiencies and a lack of cultural 'soft skills'".
Study hospitals were selected to achieve a representative sample of all people of working age admitted to Victorian public hospitals annually as a consequence of sustaining acute unintentional trauma following an analysis of the Victorian Admitted Episodes Dataset [ 15].
