Sentence examples for consequences of such mutations from inspiring English sources

To identify the functional state of the channel that this structure represents, we engineered phenylalanines at various pore-facing positions of the muscle acetylcholine (ACh) receptor (one position at a time), including the position that aligns with the native phenylalanine 246 of ELIC, and assessed the consequences of such mutations using electrophysiological and toxin-binding assays.

However, it will be crucial to determine the functional consequences of such mutations.

Studies on the molecular consequences of such mutations have often been conducted in bacterial models of complex I [58 61].

Since the bacterial complex I does not display the A/D transition this may be misleading for the study of the overall functional consequences of such mutations, not at the level of the enzyme as such, but for global consequences on the respiratory chain.

Since Beclin 1 is a well-known tumor suppressor [2], [16], we therefore wanted to test the cell biological consequence of such mutations in the context of FYVE-CENT interaction.

The consequences of expression of such mutations may be explored further by introducing such human hyperekplexia antimorphs as transgenes into mice.

An accumulation of such mutations.

I. Production and genetic analyses of such mutations.

We know that carcinogens, including toxic exposures such as radiation and chemicals, increase the frequency of such mutations.

Before his work, it was impossible to separate the contributions of such mutations from those of mutations in nuclear DNA.

Single amino acid changes are the main type of mutation causing this disease, and considerable effort has been dedicated to the understanding of the molecular consequences of such missense mutations.